Sodium Hydroxide → Sodium 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]propanoate

HRID 880093Notes

Reaction equation

HRID 880093 reaction equation
[OH-].[Na+:2].CC(OC([O:10][C:11]1[CH:16]=[C:15]([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[N:14]=[C:13]([CH:23]([CH3:29])[C:24]([O:26]CC)=[O:25])[N:12]=1)=O)(C)C>O1CCCC1>[N:17]1([C:15]2[N:14]=[C:13]([CH:23]([CH3:29])[C:24]([O-:26])=[O:25])[NH:12][C:11](=[O:10])[CH:16]=2)[CH2:18][CH2:19][O:20][CH2:21][CH2:22]1.[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 70807105HCID 70807105, compound

Product 1

HCID 136352188Sodium 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]propanoate

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

0.190 ml of 1M sodium hydroxide is added to a solution of 145 mg of ethyl 2-[4-({[(2-methylpropan-2-yl)oxy]carbonyl}oxy)-6-(morpholin-4-yl)pyrimidin-2-yl]propanoate in 5 ml of tetrahydrofuran. After stirring overnight at ambient temperature, the reaction mixture is concentrated to dryness under reduced pressure. 100 mg of sodium 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]propanoate are obtained in the form of a solid which is used as it is in the subsequent stage.

Workup

  1. concentrationthe reaction mixture is concentrated to dryness under reduced pressure

Sources & evidence

ORD record
ord-a0f935a84a564243a5bc091805d3269c
Source dataset
uspto-grants-2015_03
Patent number
US08993565B2

Reaction notes

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