反应详情

温度

120 °C

A mixture of (3-(methoxycarbonyl)phenyl)boronic acid (270 mg, 1.5 mmol), 5-bromo-1-methyl-1H-pyrazole (200 mg, 1.25 mmol), K2CO3 (518 mg, 3.75 mmol) and Pd(dppf)Cl2 (10 mg) in a mixture solution of dioxane (8 mL) and H2O (2 mL) was stirred at 120° C. for 30 min under microwave heating. The catalyst was filtered and the filtrate concentrated. The residue was then purified by column chromatography to give provide the desired product as a colorless oil (226 mg, Yield 60%). It was used directly in the next step. LCMS (m/z): 217.1.

1. temperatureheating
2. filtrationThe catalyst was filtered
3. concentrationthe filtrate concentrated
4. customThe residue was then purified by column chromatography
5. customto give