反应详情

A stirred solution of ethyl 4-[2,4-bis(benzyloxy)-6-(4-nitrophenoxy)phenyl]-2,4-dioxobutanoate (5 g, 9 mmol) and hydroxylamine hydrochloride (0.74 g, 15 mmol, 1.2 eq) in ethanol (mL 50) was refluxed for 2 hours. The solution was concentrated to a small volume and diluted with ethyl acetate. After washing with brine and drying, the solvent was removed and the residue was carefully chromatographed on silica gel eluting with hexane/ethyl acetate 6/1, to provide the title compound (4.1 g, 82% yield).

1. concentrationThe solution was concentrated to a small volume
2. additiondiluted with ethyl acetate
3. washAfter washing with brine
4. customdrying
5. customthe solvent was removed
6. customthe residue was carefully chromatographed on silica gel eluting with hexane/ethyl acetate 6/1