HRID880377

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID201262

Benzeneboronic acid, p-methoxy-

C7H9BO3

HCID68013986

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(-c2cnn(C(C)c3ccccc3)c(=O)c2-c2ccc(OC)cc2)cc1

HCID57385635

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

结构：c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1

催化剂HCID178418397

未命名化合物

溶剂HCID21886435

1,4-Dioxane--water (1/1)

C4H10O3

PROCEDURE

实验过程

Compound 6 is prepared from intermediate 1a and 4-methoxyphenylboronic acid under the conditions described for example 1 using tetrakis(triphenylphosphine)palladium(0), K2CO3 and a mixture of dioxane/water: 3/1. Compound 6 is isolated in solid form (yield: 71%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6c91be9b8d7f43b6a23026198536c850
来源数据集: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08993569B2
来源说明: uspto-grants-2015_03

反应 SMILES

Cl[C:2]1[C:3](=[O:17])[N:4]([CH:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH3:10])[N:5]=[CH:6][C:7]=1Cl.[CH3:18][O:19][C:20]1[CH:25]=[CH:24][C:23](B(O)O)=[CH:22][CH:21]=1.[C:29]([O-:32])([O-])=O.[K+].[K+]>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.O1CCOCC1.O>[CH3:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([C:2]2[C:3](=[O:17])[N:4]([CH:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH3:10])[N:5]=[CH:6][C:7]=2[C:11]2[CH:16]=[CH:15][C:14]([O:32][CH3:29])=[CH:13][CH:12]=2)=[CH:22][CH:21]=1