Potassium Carbonate → 4,5-Bis-(4-methoxy-phenyl)-2-(1-phenyl-ethyl)-2H-pyridazin-3-one

HRID 880377Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 880377
Cl[C:2]1[C:3](=[O:17])[N:4]([CH:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH3:10])[N:5]=[CH:6][C:7]=1Cl.[CH3:18][O:19][C:20]1[CH:25]=[CH:24][C:23](B(O)O)=[CH:22][CH:21]=1.[C:29]([O-:32])([O-])=O.[K+].[K+]>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.O1CCOCC1.O>[CH3:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([C:2]2[C:3](=[O:17])[N:4]([CH:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH3:10])[N:5]=[CH:6][C:7]=2[C:11]2[CH:16]=[CH:15][C:14]([O:32][CH3:29])=[CH:13][CH:12]=2)=[CH:22][CH:21]=1

Komponenten

6

Edukt 3

HCID 11430Potassium CarbonateHCID 201262(4-Methoxyphenyl)boronic acidHCID 680139864,5-dichloro-2-(1-phenylethyl)pyridazin-3(2H)-one

Produkt 1

HCID 573856354,5-Bis-(4-methoxy-phenyl)-2-(1-phenyl-ethyl)-2H-pyridazin-3-one

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418397HCID 178418397, VerbindungKatalysatorHCID 218864351,4-Dioxane--water (1/1)Lösungsmittel

Versuchsvorschrift

Compound 6 is prepared from intermediate 1a and 4-methoxyphenylboronic acid under the conditions described for example 1 using tetrakis(triphenylphosphine)palladium(0), K2CO3 and a mixture of dioxane/water: 3/1. Compound 6 is isolated in solid form (yield: 71%).

Quellen und Nachweise

ORD-Eintrag
ord-6c91be9b8d7f43b6a23026198536c850
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08993569B2

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