Dimethylformamide → 1-(2-Chlorophenyl)-2-(4-chlorophenyl)-3-(dimethylamino)prop-2-en-1-one

HRID 8804Notes

Reaction equation

HRID 8804 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:17])[CH2:9][C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=1.[CH3:18][N:19]([CH:21]=O)[CH3:20]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:17])[C:9]([C:10]1[CH:11]=[CH:12][C:13]([Cl:16])=[CH:14][CH:15]=1)=[CH:18][N:19]([CH3:21])[CH3:20]

Participants

3

Reactant 2

HCID 6228DimethylformamideHCID 3483121-(2-Chlorophenyl)-2-(4-chlorophenyl)ethanone

Product 1

HCID 686588401-(2-Chlorophenyl)-2-(4-chlorophenyl)-3-(dimethylamino)prop-2-en-1-one

Conditions

Temperature
75 °C

Procedure

To 13.2 g of 1-(2-chlorophenyl)-2-(4-chlorophenyl)ethanone in 100 mL of DMF was added 23.8 g of N,N-dimethylormamide dimethyl acetal. The mixture was stirred at 75° C. for 16 hours. The solution was then concentrated and used without further purification in the next step.

Workup

  1. concentrationThe solution was then concentrated
  2. customused without further purification in the next step

Sources & evidence

ORD record
ord-2374f352d7f2478f8a9850727af6b546
Source dataset
uspto-grants-2006_08
Patent number
US07091216B2

Reaction notes

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