反应详情

温度

52.5 °C

To a stirred solution of 4-nitro-N-prop-2-ynyl-benzamide (7.5 g, 36.7 mmol) in ethanol (150 mL) was added a solution of potassium hydroxide (4.1 g, 73.4 mmol) in ethanol (100 mL) and the mixture was stirred at 50-55° C. for 12 h. The mixture was acidified with acetic acid and concentrated to dryness in vacuo at 45-50° C. The resultant residue was extracted into ethyl acetate and the separated organic phase was washed with water; aqueous sodium bicarbonate, brine, dried over anhydrous sodium sulphate and concentrated in vacuo to afford 5-methyl-2-(4-nitrophenyl)oxazole (3.47 g, 46%) as an oil.

1. concentrationconcentrated to dryness in vacuo at 45-50° C
2. extractionThe resultant residue was extracted into ethyl acetate
3. washthe separated organic phase was washed with water
4. dry with materialaqueous sodium bicarbonate, brine, dried over anhydrous sodium sulphate
5. concentrationconcentrated in vacuo