反应详情

温度

70 °C

To a solution of benzoylacetonitrile derivative (1 eq.) in EtOH is added pyridine (1 eq.). The resulting mixture is stirred at 70° C. for 15 min then cooled at r.t. A previously stirred suspension of thiourea (2 eq.) and iodine (1 eq.) in EtOH is then slowly added. After 1 h at r.t. a cold 1M Na2S2O3 solution is added under stirring. The resulting precipitate is filtered, washed with water, and finally dried under vacuo to afford the amino-4-phenyl-thiazole-5-carbonitrile derivative.

1. temperaturethen cooled at r.t
2. additionis then slowly added
3. stirringunder stirring
4. filtrationThe resulting precipitate is filtered
5. washwashed with water
6. customfinally dried under vacuo