反应详情

温度

0 °C

A solution of compound 5 (0.85 g) and NaOH (0.304 g) in a mixture of water (9 mL), methanol (5 mL), and THF (45 mL) was stirred at reflux for 24 h and concentrated to dryness. The residue was dissolved in water, and the solution was cooled to 0° C. and adjusted to pH 7 with 10% potassium hydrogen sulfate. The mixture was concentrated to dryness, the residue was treated with methanol, and filtered to remove solids. The filtrate was concentrated to yield compound 6 as a yellow solid.

1. temperatureat reflux for 24 h
2. concentrationconcentrated to dryness
3. dissolutionThe residue was dissolved in water
4. concentrationThe mixture was concentrated to dryness
5. additionthe residue was treated with methanol
6. filtrationfiltered
7. customto remove solids
8. concentrationThe filtrate was concentrated