反应详情

Diborane (1 M, THF, 24 mL) was added at 0° C. to a solution of 6-fluoro-3,4-dihydro isoquinolin-1(2H)-one (1.14 g, 6.9 mmol) in THF (8 mL). The mixture was stirred at reflux for 18 h. It was cooled to room temperature and water was added. The mixture was extracted with dichloromethane, and the organic layer was dried over sodium sulfate and concentrated. Purification by column chromatography (hexanes:ethyl acetate 1:1) afforded the title compound.

1. temperatureat reflux for 18 h
2. extractionThe mixture was extracted with dichloromethane
3. dry with materialthe organic layer was dried over sodium sulfate
4. concentrationconcentrated
5. customPurification by column chromatography (hexanes:ethyl acetate 1:1)