Water → HCID 58097333, compound

HRID 880692Notes

Reaction equation

HRID 880692 reaction equation
[CH3:1][C:2]([CH3:8])([CH3:7])[CH2:3][C:4](Cl)=[O:5].[Br:9][C:10]1[CH:15]=[CH:14][C:13]([NH2:16])=[C:12]([C:17]([F:20])([F:19])[F:18])[CH:11]=1.O>C(#N)C>[Br:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16][C:4](=[O:5])[CH2:3][C:2]([CH3:8])([CH3:7])[CH3:1])=[C:12]([C:17]([F:18])([F:19])[F:20])[CH:11]=1

Participants

5

Reactant 3

HCID 962WaterHCID 679604-Bromo-2-(trifluoromethyl)anilineHCID 815143,3-Dimethylbutanoyl chloride

Product 1

HCID 58097333HCID 58097333, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

3,3-Dimethylbutanoyl chloride (617 mg, 0.64 mL, 4.6 mmol) was added to a solution of 4-Bromo-2-trifluoromethyl-phenylamine (1.0 g, 4.16 mmol) in acetonitrile (10 mL). The reaction mixture was stirred at room temperature overnight. Water was added to the mixture and the precipitate formed collected to give the title compound as a powder (1.1 g, 79% yield).

Workup

  1. customthe precipitate formed
  2. customcollected

Sources & evidence

ORD record
ord-4157cdd4508e488996fad131ebe443e6
Source dataset
uspto-grants-2015_03
Patent number
US08993593B2

Reaction notes

Loading…