3-bromo-4-(iodomethyl)-1-tert-pentyl-1H-pyrazole → 2'-tert-pentyl-4',6'-dihydrospiro[piperidine-4,5'-pyrazolo[3,4-c]pyridin]-7'(2'H)-one
Reaction equation
Cl.[CH:2]([N:5]1[CH:13]=[C:12]2[C:7]([C:8](=[O:19])[NH:9][C:10]3([CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)[CH2:11]2)=[N:6]1)([CH3:4])[CH3:3].Br[C:21]1[C:25](CI)=CN(C(CC)(C)C)N=1>>[C:2]([N:5]1[CH:13]=[C:12]2[C:7]([C:8](=[O:19])[NH:9][C:10]3([CH2:14][CH2:15][NH:16][CH2:17][CH2:18]3)[CH2:11]2)=[N:6]1)([CH2:21][CH3:25])([CH3:4])[CH3:3]Participants
3
Procedure
The title compound was prepared by a method analogous to that described for Intermediate 3 in Steps 4-8, using 3-bromo-4-(iodomethyl)-1-tert-pentyl-1H-pyrazole. +ESI (M+H) 277.3; 1H NMR (400 MHz, CD3OD, δ): 7.67 (s, 1H), 3.22-3.37 (m, 4H), 2.93 (s, 2H), 1.92 (q, J=7.61 Hz, 2H), 1.88-2.05 (m, 4H), 1.57 (s, 6H), 0.67 (t, J=7.41 Hz, 3H).
Sources & evidence
- ORD record
- ord-2d9d55d5a2d449c1a8bd66a75d6ca726
- Source dataset
- uspto-grants-2015_03
- Patent number
- US08993586B2
Reaction notes
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