HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-bromo-4-(iodomethyl)-1-tert-pentyl-1H-pyrazole → 2'-tert-pentyl-4',6'-dihydrospiro[piperidine-4,5'-pyrazolo[3,4-c]pyridin]-7'(2'H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-bromo-4-(iodomethyl)-1-tert-pentyl-1H-pyrazole | HCID 67491491 | — |
| Reactant | 2'-isopropyl-4',6'-dihydrospiro[piperidine-4,5'-pyrazolo[3,4-c]pyridin]-7'(2'H)-one hydrochloride | HCID 67491564 | — |
| Product | 2'-tert-pentyl-4',6'-dihydrospiro[piperidine-4,5'-pyrazolo[3,4-c]pyridin]-7'(2'H)-one | HCID 67491658 | — |
Reaction Steps
The title compound was prepared by a method analogous to that described for Intermediate 3 in Steps 4-8, using 3-bromo-4-(iodomethyl)-1-tert-pentyl-1H-pyrazole. +ESI (M+H) 277.3; 1H NMR (400 MHz, CD3OD, δ): 7.67 (s, 1H), 3.22-3.37 (m, 4H), 2.93 (s, 2H), 1.92 (q, J=7.61 Hz, 2H), 1.88-2.05 (m, 4H), 1.57 (s, 6H), 0.67 (t, J=7.41 Hz, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08993586B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-2d9d55d5a2d449c1a8bd66a75d6ca726 |
| Source note | uspto-grants-2015_03 |