HCID 67491524, compound → HCID 67491681, compound

HRID 880946Notes

Reaction equation

HRID 880946 reaction equation
CN1C(=O)C2C(=CC=C(C(O)=O)C=2)N1.[CH3:15][O:16][C:17]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23]([C:26]([O:28]C)=[O:27])[CH:24]=2)[N:19](C(OCC)=O)[N:18]=1>>[CH3:15][O:16][C:17]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23]([C:26]([OH:28])=[O:27])[CH:24]=2)[NH:19][N:18]=1

Participants

3

Reactant 2

HCID 67491524HCID 67491524, compoundHCID 67491709HCID 67491709, compound

Product 1

HCID 67491681HCID 67491681, compound

Procedure

The title compound was prepared by a method analogous to that described for Intermediate 16, using 1-ethyl 5-methyl 3-methoxy-1H-indazole-1,5-dicarboxylate, the regioisomeric product formed in Step 3. +ESI (M+H) 193.1; 1H NMR (400 MHz, DMSO-d6, δ): 12.65 (br. s., 1H), 12.26 (s, 1H), 8.18 (s, 1H), 7.86 (dd, J=8.9, 1.5 Hz, 1H), 7.38 (d, J=8.8 Hz, 1H), 3.99 (s, 3H).

Sources & evidence

ORD record
ord-05b2bedef7394d68bcc3b3a71685e6ec
Source dataset
uspto-grants-2015_03
Patent number
US08993586B2

Reaction notes

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