2-(Methylamino)quinoline-6-carboxylic acid → 2-(Methylamino)quinoline-7-carboxylic acid

HRID 880960Notes

Reaction equation

HRID 880960 reaction equation
[CH3:1][NH:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8](C(O)=O)[CH:9]=2)[N:4]=1.C([O:18][C:19](C1C=C2C(C=CC=[N+]2[O-])=CC=1)=[O:20])C>>[CH3:1][NH:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][C:7]([C:19]([OH:20])=[O:18])=[CH:8][CH:9]=2)[N:4]=1

Participants

3

Reactant 2

HCID 674914872-(Methylamino)quinoline-6-carboxylic acidHCID 674915557-(Ethoxycarbonyl)quinoline 1-oxide

Product 1

HCID 674915172-(Methylamino)quinoline-7-carboxylic acid

Procedure

The title compound was prepared by a method analogous to that described in Steps 3-4 of Intermediate 20, using 7-(ethoxycarbonyl)quinoline 1-oxide. 1H NMR (400 MHz, DMSO-d6, δ): 8.08 (s, 1H), 7.90 (d, 1H), 7.71-7.62 (m, 2H), 7.21 (s, 1H), 6.84 (d, 1H), 2.91 (d, 3H).

Sources & evidence

ORD record
ord-035a8e60da8c442591cab97c04687667
Source dataset
uspto-grants-2015_03
Patent number
US08993586B2

Reaction notes

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