7-Bromoisoquinolin-3-amine → 3-Aminoisoquinoline-7-carboxylic acid

HRID 880995Notes

Reaction equation

HRID 880995 reaction equation
FC(F)(F)[C:3]1[CH:4]=[C:5]([C:12]([OH:14])=[O:13])[CH:6]=[C:7]2[C:11]=1N[N:9]=[CH:8]2.BrC1C=C2C([CH:22]=[C:23](N)[N:24]=C2)=CC=1>>[NH2:24][C:23]1[N:9]=[CH:8][C:7]2[C:11]([CH:22]=1)=[CH:3][CH:4]=[C:5]([C:12]([OH:14])=[O:13])[CH:6]=2

Participants

3

Reactant 2

HCID 529877577-Bromoisoquinolin-3-amineHCID 674918107-(trifluoromethyl)-1H-indazole-5-carboxylic acid

Product 1

HCID 674913293-Aminoisoquinoline-7-carboxylic acid

Procedure

The title compound was prepared by a method analogous to that described in Steps 3-4 of Intermediate 21, using 7-bromoisoquinolin-3-amine. +ESI (M+H) 189.2; 1H NMR (400 MHz, CD3OD, δ): 8.87 (s, 1H), 8.52 (d, J=0.78 Hz, 1H), 7.98 (dd, J=8.78, 1.76 Hz, 1H), 7.54 (d, J=8.78 Hz, 1H), 6.77 (s, 1H).

Sources & evidence

ORD record
ord-40aae240cfb6491aa15a0fc44c1785ff
Source dataset
uspto-grants-2015_03
Patent number
US08993586B2

Reaction notes

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