4-(3-Bromopropoxy)-2-fluorobenzonitrile → 4-(3-{4-[3-(4-Cyanophenoxy)propyl]-1-piperidinyl}propoxy)-2-fluorobenzonitrile
Reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:18]=[CH:17][C:14]([C:15]#[N:16])=[CH:13][CH:12]=2)[CH2:3][CH2:2]1.Br[CH2:20][CH2:21][CH2:22][O:23][C:24]1[CH:31]=[CH:30][C:27]([C:28]#[N:29])=[C:26]([F:32])[CH:25]=1>>[C:15]([C:14]1[CH:13]=[CH:12][C:11]([O:10][CH2:9][CH2:8][CH2:7][CH:4]2[CH2:5][CH2:6][N:1]([CH2:20][CH2:21][CH2:22][O:23][C:24]3[CH:31]=[CH:30][C:27]([C:28]#[N:29])=[C:26]([F:32])[CH:25]=3)[CH2:2][CH2:3]2)=[CH:18][CH:17]=1)#[N:16]Participants
3
Procedure
As described in Production Example 7, 0.12 g of 4-[3-(4-piperidinyl)propoxy]benzonitrile and 0.15 g of 4-(3-bromopropoxy)-2-fluorobenzonitrile were used to provide 0.10 g of 4-(3-{4-[3-(4-cyanophenoxy)propyl]-1-piperidinyl}propoxy)-2-fluorobenzonitrile as white solid form.
Sources & evidence
- ORD record
- ord-47f8b0e63b754d5ab5eb47411cec6a6a
- Source dataset
- uspto-grants-2015_03
- Patent number
- US08993603B2
Reaction notes
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