HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(3-Bromopropoxy)-2-fluorobenzonitrile → 4-(3-{4-[3-(4-Cyanophenoxy)propyl]-1-piperidinyl}propoxy)-2-fluorobenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(3-Bromopropoxy)-2-fluorobenzonitrile | HCID 23033963 | — |
| Reactant | 4-[3-(4-Piperidinyl)propoxy]benzonitrile | HCID 59263019 | — |
| Product | 4-(3-{4-[3-(4-Cyanophenoxy)propyl]-1-piperidinyl}propoxy)-2-fluorobenzonitrile | HCID 68690723 | 48.3% |
Reaction Steps
As described in Production Example 7, 0.12 g of 4-[3-(4-piperidinyl)propoxy]benzonitrile and 0.15 g of 4-(3-bromopropoxy)-2-fluorobenzonitrile were used to provide 0.10 g of 4-(3-{4-[3-(4-cyanophenoxy)propyl]-1-piperidinyl}propoxy)-2-fluorobenzonitrile as white solid form.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08993603B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-47f8b0e63b754d5ab5eb47411cec6a6a |
| Source note | uspto-grants-2015_03 |