Formic Acid → 5-Benzimidazolecarboxylic acid

HRID 881040Notes

Reaction equation

HRID 881040 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[NH2:11])[C:5]([OH:7])=[O:6].[CH:12](O)=O>>[NH:1]1[C:2]2[CH:3]=[C:4]([C:5]([OH:7])=[O:6])[CH:8]=[CH:9][C:10]=2[N:11]=[CH:12]1

Participants

3

Reactant 2

HCID 284Formic AcidHCID 692633,4-Diaminobenzoic acid

Product 1

HCID 4594565-Benzimidazolecarboxylic acid

Procedure

3,4-diaminobenzoic acid (5 g, 32 mmol) and formic acid (20 ml) were mixed and refluxed overnight. Formic acid was removed on rotavapour and water added to the residue to obtain the solid. Solid was filtered and dried to obtain the title compound quantitatively.

Workup

  1. temperaturerefluxed overnight
  2. customFormic acid was removed on rotavapour and water
  3. additionadded to the residue
  4. customto obtain the solid
  5. filtrationSolid was filtered
  6. customdried

Sources & evidence

ORD record
ord-35751864a8ba44259e31706addd54591
Source dataset
uspto-grants-2015_03
Patent number
US08993612B2

Reaction notes

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