1-Methyl-4-(methylamino)piperidine → N-((2-chloro-4-morpholinothieno[2,3-d]pyrimidin-6-yl)methyl)-N,1-dimethylpiperidin-4-amine

HRID 881300Notes

Reaction equation

HRID 881300 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([NH:8][CH3:9])[CH2:4][CH2:3]1.[Cl:10][C:11]1[N:12]=[C:13]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[C:14]2[CH:19]=[C:18]([CH:20]=O)[S:17][C:15]=2[N:16]=1>>[Cl:10][C:11]1[N:12]=[C:13]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[C:14]2[CH:19]=[C:18]([CH2:20][N:8]([CH3:9])[CH:5]3[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]3)[S:17][C:15]=2[N:16]=1

Participants

3

Reactant 2

HCID 5663231-Methyl-4-(methylamino)piperidineHCID 568338442-Chloro-4-morpholinothieno[2,3-d]pyrimidine-6-carbaldehyde

Product 1

HCID 86623517N-((2-chloro-4-morpholinothieno[2,3-d]pyrimidin-6-yl)methyl)-N,1-dimethylpiperidin-4-amine

Procedure

1-Methyl-4-(methylamino)-piperidine was reacted with 2-chloro-4-morpholinothieno[2,3-d]pyrimidine-6-carbaldehyde via General Procedure B-3. Purification on silica yielded (2-chloro-4-morpholin-4-yl-thieno[2,3-d]pyrimidin-6-ylmethyl)-methyl-(1-methyl-piperidin-4-yl)-amine.

Workup

  1. customPurification on silica

Sources & evidence

ORD record
ord-9b9237af1d61474ab4937c54e66c245f
Source dataset
uspto-grants-2015_03
Patent number
US08993563B2

Reaction notes

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