Hydrochloric Acid → HCID 43810645, compound

HRID 881405Notes

Reaction equation

HRID 881405 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=2)(=[O:16])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>CO.ClCCl.C(OCC)C>[ClH:24].[F:23][C:19]1[CH:18]=[C:17]([S:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)(=[O:15])=[O:16])[CH:22]=[CH:21][CH:20]=1

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 46180234HCID 46180234, compound

Product 1

HCID 43810645HCID 43810645, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

4-(3-Fluoro-benzenesulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (919 mg) was dissolved in methanol (10 ml) and dichloromethane (5 ml), 2M HCl in diethyl ether (12 ml) was added and the reaction mixture was stirred at room temperature overnight. Volatiles were removed in vacuo to yield 4-(3-fluoro-benzenesulfonyl)-piperazine hydrochloride salt (807 mg).

Workup

  1. customVolatiles were removed in vacuo

Sources & evidence

ORD record
ord-a2713797736b463da29884165ed12da3
Source dataset
uspto-grants-2015_03
Patent number
US08993563B2

Reaction notes

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