Hydrochloric Acid → Piperazine, 1-[(1-methyl-1H-imidazol-4-yl)sulfonyl]-, hydrochloride (1:1)

HRID 881408Notes

Reaction equation

HRID 881408 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[N:18]=[CH:19][N:20]([CH3:22])[CH:21]=2)(=[O:16])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:23]>CO.ClCCl.C(OCC)C>[ClH:23].[CH3:22][N:20]1[CH:21]=[C:17]([S:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)(=[O:15])=[O:16])[N:18]=[CH:19]1

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 58561856HCID 58561856, compound

Product 1

HCID 66934082Piperazine, 1-[(1-methyl-1H-imidazol-4-yl)sulfonyl]-, hydrochloride (1:1)

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

4-(1-Methylimidazole-4-sulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (730 mg) was dissolved in methanol (10 ml) and dichloromethane (5 ml), 2M HCl in diethyl ether (11 ml) was added and the reaction mixture was stirred at room temperature overnight. Volatiles were removed in vacuo to yield 4-(1-methylimidazole-4-sulfonyl)-piperazine hydrochloride salt (704 mg).

Workup

  1. customVolatiles were removed in vacuo

Sources & evidence

ORD record
ord-02d757ced25d49a2b9919f7bcac74f50
Source dataset
uspto-grants-2015_03
Patent number
US08993563B2

Reaction notes

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