Hydrochloric Acid → 1-(4-Fluorobenzene-1-sulfonyl)piperazine--hydrogen chloride (1/1)

HRID 881410Notes

Reaction equation

HRID 881410 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)(=[O:16])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>CO.ClCCl.C(OCC)C>[ClH:24].[F:23][C:20]1[CH:19]=[CH:18][C:17]([S:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)(=[O:16])=[O:15])=[CH:22][CH:21]=1

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 4634543HCID 4634543, compound

Product 1

HCID 173683141-(4-Fluorobenzene-1-sulfonyl)piperazine--hydrogen chloride (1/1)

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

4-(4-Fluoro-benzenesulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (937 mg) was dissolved in methanol (10 ml) and dichloromethane (5 ml), 2M HCl in diethyl ether (13.6 ml) was added and the reaction mixture was stirred at room temperature overnight. Volatiles were removed in vacuo to yield 4-(4-fluoro-benzenesulfonyl)-piperazine hydrochloride salt (819 mg).

Workup

  1. customVolatiles were removed in vacuo

Sources & evidence

ORD record
ord-8b177e7ee8e244dfb4364fdfe1412b85
Source dataset
uspto-grants-2015_03
Patent number
US08993563B2

Reaction notes

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