2-Aminopyrimidine-5-boronic acid, pinacol ester → 2-(4-((2-(2-Aminopyrimidin-5-yl)-4-morpholinothieno[2,3-d]pyrimidin-6-yl)methyl)piperazin-1-yl)ethanol

Participants

Role	Name	HCID	Charge
Reactant	2-Aminopyrimidine-5-boronic acid, pinacol ester	HCID 17750212	—
Reactant	2-(4-((2-Chloro-4-morpholinothieno[2,3-d]pyrimidin-6-yl)methyl)piperazin-1-yl)ethanol	HCID 58233992	—
Product	2-(4-((2-(2-Aminopyrimidin-5-yl)-4-morpholinothieno[2,3-d]pyrimidin-6-yl)methyl)piperazin-1-yl)ethanol	HCID 58233900	—

Reaction Steps

2-(4-((2-chloro-4-morpholinothieno[2,3-d]pyrimidin-6-yl)methyl)piperazin-1-yl)ethanol (175 mg) was utilized in a Suzuki coupling with 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine according to General Procedure Suzuki to provide 385 (20 mg) after reverse phase HPLC purification. MS (Q1) 457 (M)+

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08993563B2
Source dataset	uspto-grants-2015_03
ORD ID	ord-282dc23277db49d1bc197d9dd9f2147f
Source note	uspto-grants-2015_03