Water → 1-Fluoro-4-methoxy-5-methyl-2-nitrobenzene

HRID 881606Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 881606
[F:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([OH:11])=[C:4]([CH3:12])[CH:3]=1.[C:13](=O)([O-])[O-].[K+].[K+].IC.O>CN(C)C=O>[F:1][C:2]1[CH:3]=[C:4]([CH3:12])[C:5]([O:11][CH3:13])=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9]

Komponenten

6

Edukt 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 108210594-Fluoro-2-methyl-5-nitrophenol

Produkt 1

HCID 598501391-Fluoro-4-methoxy-5-methyl-2-nitrobenzeneAusbeute 81,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a solution of 4-fluoro-2-methyl-5-nitrophenol (0.5 g) in N,N-dimethylformamide (5 mL) were added potassium carbonate (0.44 g) and iodomethane (0.46 g), and this mixture was stirred at room temperature overnight. To this reaction mixture was added water and the precipitated solid was collected by filtration, and washed with water and n-hexane to give the title compound (0.44 g).

Aufarbeitung

  1. filtrationthe precipitated solid was collected by filtration
  2. washwashed with water and n-hexane

Quellen und Nachweise

ORD-Eintrag
ord-c1628d2864f44c8d938e5049669a897d
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08993616B2

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