Acetonitrile → HCID 4326084, compound

HRID 881785Notes

Reaction equation

HRID 881785 reaction equation
[OH-:1].[NH4+:2].CO[C:5]1[C:10]([N+:11]([O-])=[O:12])=[N:9][C:8]([N+:14]([O-:16])=[O:15])=[C:7](OC)[N:6]=1.C(#[N:21])C>>[NH2:2][C:5]1[C:10]([N+:11]([O-:12])=[O:1])=[N:9][C:8]([N+:14]([O-:16])=[O:15])=[C:7]([NH2:21])[N:6]=1

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 14923Ammonium HydroxideHCID 4913001HCID 4913001, compound

Product 1

HCID 4326084HCID 4326084, compound

Conditions

Temperature
65 °C

Procedure

Ammonium hydroxide (28%, 60 mL) was added drop wise to a slurry of 2,6-dimethoxy 3,5-dinitro pyrazine (10.0 g, 43.5 mmol) in acetonitrile (50 mL). Upon addition, the yellow slurry became red/yellow in color and eventually became a red solution. As the solution was heated at 65° C. for an hour, yellow precipitate (8.0 g, 92.2%) began to form, which was filtered hot and allowed to air dry.

Workup

  1. additionUpon addition
  2. customto form
  3. filtrationwhich was filtered hot
  4. customto air dry

Sources & evidence

ORD record
ord-e6f8abe82ce8491eb72dcdd1d8693d44
Source dataset
uspto-grants-2015_03
Patent number
US08993713B1

Reaction notes

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