反应详情

温度

125 °C

A suspension of 1,1,2-trimethylbenz[e]indol-6,8-disulfonate (4.82 g, 13.0 mmol), bromohexanoic acid (25 g, 130 mmol) in a 250 mL round bottom flask was heated in an oil bath at 125° C. for 40 h. After cooling to ambient temperature ethyl acetate (100 mL) was added the solid was triturated. Filtered to collect the solid, washed with ethyl acetate (3×50 mL), ether (2×20 mL) and dried. Further drying in an oven at 40° C. under high vacuum for 18 h gave 4.41 g (70.0%) of the product.

1. additionwas added the solid
2. customwas triturated
3. filtrationFiltered
4. customto collect the solid
5. washwashed with ethyl acetate (3×50 mL), ether (2×20 mL)
6. customdried
7. customFurther drying in an oven at 40° C. under high vacuum for 18 h