Thionyl Chloride → 2-(4-Methoxy-benzyl)-2H-tetrazole-5-carbonyl chloride

HRID 881872Notes

Reaction equation

HRID 881872 reaction equation
[CH3:1][O:2][C:3]1[CH:17]=[CH:16][C:6]([CH2:7][N:8]2[N:12]=[N:11][C:10]([C:13](O)=[O:14])=[N:9]2)=[CH:5][CH:4]=1.O=S(Cl)[Cl:20]>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:17]=[CH:16][C:6]([CH2:7][N:8]2[N:12]=[N:11][C:10]([C:13]([Cl:20])=[O:14])=[N:9]2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 135962442-(4-Methoxybenzyl)-2h-tetrazole-5-carboxylic acid

Product 1

HCID 596077322-(4-Methoxy-benzyl)-2H-tetrazole-5-carbonyl chloride

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
80 °C

Procedure

Next, to a mixture of 2-(4-methoxy-benzyl)-2H-tetrazole-5-carboxylic acid in Toluene (15 ml) at room temperature is added SOCl2 (1 ml, 13.70 mmol) and the mixture is heated at 80° C. for 3 hr. The reaction mixture is concentrated under reduced pressure to give the crude product, which is used without further purification.

Workup

  1. concentrationThe reaction mixture is concentrated under reduced pressure

Sources & evidence

ORD record
ord-986d4b3515bc4c3b8d2b373541b71c37
Source dataset
uspto-grants-2015_03
Patent number
US08993631B2

Reaction notes

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