HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 881872Generated: October 26, 2026
Thionyl Chloride → 2-(4-Methoxy-benzyl)-2H-tetrazole-5-carbonyl chloride
https://huagongshe.com/reaction/881872
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-(4-Methoxybenzyl)-2h-tetrazole-5-carboxylic acid | HCID 13596244 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-(4-Methoxy-benzyl)-2H-tetrazole-5-carbonyl chloride | HCID 59607732 | — |
Reaction Steps
Next, to a mixture of 2-(4-methoxy-benzyl)-2H-tetrazole-5-carboxylic acid in Toluene (15 ml) at room temperature is added SOCl2 (1 ml, 13.70 mmol) and the mixture is heated at 80° C. for 3 hr. The reaction mixture is concentrated under reduced pressure to give the crude product, which is used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08993631B2 |
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| Source dataset | uspto-grants-2015_03 |
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| ORD ID | ord-986d4b3515bc4c3b8d2b373541b71c37 |
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| Source note | uspto-grants-2015_03 |
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