Trifluoroacetic acid → HCID 89464480, compound

HRID 881980Notes

Reaction equation

HRID 881980 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][CH:11]([CH2:14][NH:15]C(=O)[O-])[CH2:10][CH2:9]2)[CH:5]=[CH:4][N:3]=1.[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22]>C(Cl)Cl>[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22].[Cl:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][CH:11]([CH2:14][NH2:15])[CH2:10][CH2:9]2)[CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 131732638HCID 131732638, compound

Product 1

HCID 89464480HCID 89464480, compoundYield 74.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (1-(2-chloropyrimidin-4-yl)piperidin-4-yl)methylcarbamate (Example 11, step i, 2.32 g, 6.73 mmol) in CH2Cl2 (30 ml) was added trifluoroacetic acid (6.0 ml, 81 mmol). After stirring for 3 h at room temperature the solvents were removed under reduced pressure to give (1-(2-chloropyrimidin-4-yl)piperidin-4-yl)methanamine 2,2,2-trifluoroacetate as a white solid (1.71 g). The crude product was used in the next step without further purification.

Workup

  1. customwere removed under reduced pressure

Sources & evidence

ORD record
ord-80a8069356cb43cca90312ea818e22bb
Source dataset
uspto-grants-2015_03
Patent number
US08993757B2

Reaction notes

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