HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Phenethylpiperazin-2-one → tert-Butyl 9-methyl-2-(2-oxo-4-phenethylpiperazin-1-yl)-5,7,8,9-tetrahydro-6H-pyrido[3',4':4,5]pyrrolo[2,3-b]pyridine-6-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Phenethylpiperazin-2-one | HCID 8547165 | — |
| Reactant | tert-Butyl 2-bromo-9-methyl-5,7,8,9-tetrahydro-6H-pyrido[3',4':4,5]pyrrolo[2,3-b]pyridine-6-carboxylate | HCID 71551310 | — |
| Product | tert-Butyl 9-methyl-2-(2-oxo-4-phenethylpiperazin-1-yl)-5,7,8,9-tetrahydro-6H-pyrido[3',4':4,5]pyrrolo[2,3-b]pyridine-6-carboxylate | HCID 67988824 | 67.5% |
Reaction Steps
tert-Butyl 2-bromo-9-methyl-5,7,8,9-tetrahydro-6H-pyrido[3′,4′:4,5]pyrrolo[2,3-b]pyridine-6-carboxylate (86 mg, 0.23 mmol) and 4-phenethylpiperazin-2-one (56 mg, 0.27 mmol) were reacted according to Example 2 (step e) to provide the title compound (76 mg, 67%) as a yellow powder: ESI MS m/z 490 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08993765B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-6249e7dac6804b33874edce322f987d6 |
| Source note | uspto-grants-2015_03 |