反应详情

To a solution of 2-methyl-7-trimethylsilanylethynyl-quinoline (140 mg, 0.59 mmol, 1.0 eq) in solution in MeOH (5 mL) was added K2CO3 (324 mg, 2.34 mmol, 4 eq), and the resulting mixture was stirred overnight at room temperature. The solvent was then removed under reduced pressure and water was then added. The aqueous layer was extracted twice with cyclohexane, and then the combined organic layers were washed with brine and dried over MgSO4. After filtration and concentration under reduced pressure the crude product was purified by column chromatography on silica gel (Cyclohexane-EtOAc 99:1) to afford 84 mg of 7-ethynyl-2-methyl-quinoline as a yellow crystal (86%).

1. customThe solvent was then removed under reduced pressure and water
2. additionwas then added
3. extractionThe aqueous layer was extracted twice with cyclohexane
4. washthe combined organic layers were washed with brine
5. dry with materialdried over MgSO4
6. filtrationAfter filtration and concentration under reduced pressure the crude product
7. customwas purified by column chromatography on silica gel (Cyclohexane-EtOAc 99:1)