Potassium Hydroxide → HCID 16679760, compound

HRID 882322Notes

Reaction equation

HRID 882322 reaction equation
[C:1]([S:5][CH2:6][C:7]1([CH3:14])[NH:11][C:10](=[O:12])[NH:9][C:8]1=[O:13])([CH3:4])([CH3:3])[CH3:2].[OH-:15].[K+]>C1(C)C=CC=CC=1>[C:10]([NH:11][C@:7]([CH3:14])([C:8]([OH:15])=[O:13])[CH2:6][S:5][C:1]([CH3:4])([CH3:3])[CH3:2])(=[O:12])[NH2:9]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 11195294HCID 11195294, compound

Product 1

HCID 16679760HCID 16679760, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
95 °C

Procedure

First, 5-tert-butylthiomethyl-5-methylhydantoin (5 g, 23 mmol) was mixed with a 73% aqueous potassium hydroxide solution (5.7 g) and toluene (10 ml), and the mixture was heated to 95° C. and stirred for 51 hours. The HPLC analysis of the reaction solution showed the production of the title compound in a reaction yield of 90%.

Sources & evidence

ORD record
ord-46feeaee623f45e29eedca3210e15a8c
Source dataset
uspto-grants-2015_03
Patent number
US08993800B2

Reaction notes

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