Acetonitrile → 3-(3-(3-Benzyloxy-propoxy)-phenyl)-3-hydroxy-propionitrile

反応式

[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[CH:16]=[O:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:21](#[N:23])[CH3:22]>>[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:14]=[C:15]([CH:16]([OH:17])[CH2:22][C:21]#[N:23])[CH:18]=[CH:19][CH:20]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

反応物 2

HCID 6342Acetonitrile

HCID 866376223-(3-(Benzyloxy)propoxy)benzaldehyde

生成物 1

HCID 673169703-(3-(3-Benzyloxy-propoxy)-phenyl)-3-hydroxy-propionitrile

実験手順

Addition of acetonitrile to 3-(3-benzyloxy-propoxy)-benzaldehyde gave 3-(3-(3-benzyloxy-propoxy)-phenyl)-3-hydroxy-propionitrile as yellow oil. Yield (0.94 g, 54%): 1H NMR (400 MHz, CDCl3) δ 7.23-7.38 (m, 6H), 6.90-6.96 (m, 2H), 6.81-6.86 (m, 1H), 5.00 (m, 1H), 4.53 (s, 2H), 4.10 (t, J=6.2 Hz, 2H), 3.67 (t, J=6.0, 2H), 2.75 (t, J=6.4, 2H), 2.04-2.13 (m, 2H).

出典と根拠

ORDレコード: ord-572d1474e40d4661ad87f0e08ebde801
出典データセット: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08993807B2

反応ノート

読み込み中…