huagongshe.com
HRID882521

反应详情

EQUATION

反应方程式

HRID 882521 的结构方程式

REACTANTS

反应物

2
结构：[O-][Cl+3]([O-])([O-])O
HCID24247

Perchloric acid

HClO4

结构：C[C@@H]1C[C@@H](Cc2ccc(-c3ccccc3)cc2)N(C(=O)C(C)(C)C)C1=O
HCID66738857

(3R,5S)-5-([1,1′-Biphenyl]-4-ylmethyl)-1-(2,2-dimethyl-1-oxopropyl)-3-methyl-2-pyrrolidinone

C23H27NO2

PRODUCTS

生成物

1
结构：CCOC(=O)[C@H](C)C[C@H](N)Cc1ccc(-c2ccccc2)cc1
HCID25017087

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

0.5 g (3R,5S)-5-biphenyl-4-ylmethyl-1-(2,2-dimethylpropionyl)-3-methylpyrrolidin-2-one, 5 ml ethanol and 0.3 ml perchloric acid were heated at about 80-120° C. for about 24 hours. The mixture was evaporated to dryness to obtain (2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid ethyl ester (perchlorate salt). 1H NMR (CDCl3): 1.17 (3H), 1.20 (3H), 1.98 (2H), 2.76 (1H), 2.96 (1H), 3.29 (1H), 3.82 (1H), 3.96 (2H), 7.32-7.59 (13H), 8.21 (3H).

WORKUP

后处理

  1. customThe mixture was evaporated to dryness