Hydrochloric Acid → HCID 71073521, compound

HRID 882570Notes

Reaction equation

HRID 882570 reaction equation
[NH2:1][C@H:2]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[Cl:14])[CH2:3][C:4]([OH:6])=[O:5].Cl.[CH3:16][CH2:17]O>>[CH2:16]([O:5][C:4](=[O:6])[CH2:3][C@H:2]([NH2:1])[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[Cl:14])[CH3:17]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 5706681(R)-3-amino-4-(2-chlorophenyl)butanoic acid

Product 1

HCID 71073521HCID 71073521, compound

Procedure

(R)-3-Amino-4-(2-chloro-phenyl)-butyric acid (10 g, 50 mmol) was dissolved in absolute EtOH (250 mL). Concentrated HCl (2 mL) was added and the mixture was heated to reflux overnight. The product was vacuumed to dryness and azeotroped with toluene (4×50 mL), then placed under high vacuum overnight to yield the title compound as a white solid (10 g).

Workup

  1. temperaturethe mixture was heated
  2. temperatureto reflux overnight
  3. customazeotroped with toluene (4×50 mL)
  4. customplaced under high vacuum overnight

Sources & evidence

ORD record
ord-130124c120a74b288c7aa47189aa9057
Source dataset
uspto-grants-2015_03
Patent number
US08993752B2

Reaction notes

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