HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (1S,2R)-1-amino-2-phenyl-N-propylcyclopropanecarboxamide trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Propylamine | HCID 7852 | — |
| Reactant | (1S,2R)-N-Boc-1-amino-2-phenylcyclopropanecarboxylic acid | HCID 7009512 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Product | (1S,2R)-1-amino-2-phenyl-N-propylcyclopropanecarboxamide trifluoroacetate | HCID 71294530 | 85% |
Reaction Steps
The title compound was prepared by coupling commercially available (1S,2R)-1-[(tert-butoxycarbonyl)amino]-2-phenylcyclopropanecarboxylic acid with n-propylamine in the presence of O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (HATU) and subsequent Boc detachment with trifluoroacetic acid (yield: 85% of theory over both stages).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08992932B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-9e117ccc27b94790bb801a036ff93700 |
| Source note | uspto-grants-2015_03 |