Z-Val-Pro-Val-Pro Ara-C → H-Val-Pro-Val-Pro Ara-C

Participants

Reaction Steps

A solution of the corresponding Ara-C-tetrapeptide-Z-protected (D) (24.7 mg, 0.03 mmol) in methanol containing Pd/C (10% wt/wt) (11.5 mg) was hydrogenated at 25 psi at room temperature for 2 h. The reaction mixture was filtered, and the filtrate was evaporated to dryness, under reduced pressure, to give D (90% yield).

Provenance & Evidence