HRID882697

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)OC(C)(C)C)C(C)C

HCID131729873

未命名化合物

PRODUCTS

生成物

结构：CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(=O)N1CCC[C@H]1C(=O)O

HCID131727672

未命名化合物

收率 84%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

A solution of Z-Val-Pro-Val-Pro-OtBu [SEQ ID No: 9] (1.1 mmol) was treated with trifluoroacetic acid (2.76 mL, 3.58 mmol) in dichloromethane (4.85 mL), the reaction was stirred at room temperature for 3 h. Then, the solution was evaporated to dryness and the residue was lyophilized to give Y (84% yield).

WORKUP

后处理

customThen, the solution was evaporated to dryness
customto give Y (84% yield)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8d35f87a81c945129aca7186ba749bca
来源数据集: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08236756B2
来源说明: uspto-grants-2012_08

反应 SMILES

[NH:1]([C:34]([O:36][CH2:37][C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)=[O:35])[C@H:2]([C:6]([N:8]1[CH2:33][CH2:32][CH2:31][C@H:9]1[C:10]([NH:12][C@H:13]([C:17]([N:19]1[CH2:30][CH2:29][CH2:28][C@H:20]1[C:21]([O:23]C(C)(C)C)=[O:22])=[O:18])[CH:14]([CH3:16])[CH3:15])=[O:11])=[O:7])[CH:3]([CH3:5])[CH3:4].FC(F)(F)C(O)=O>ClCCl>[NH:1]([C:34]([O:36][CH2:37][C:38]1[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=1)=[O:35])[C@H:2]([C:6]([N:8]1[CH2:33][CH2:32][CH2:31][C@H:9]1[C:10]([NH:12][C@H:13]([C:17]([N:19]1[CH2:30][CH2:29][CH2:28][C@H:20]1[C:21]([OH:23])=[O:22])=[O:18])[CH:14]([CH3:16])[CH3:15])=[O:11])=[O:7])[CH:3]([CH3:4])[CH3:5]