反应详情

温度

70 °C

Dimethylformamide (0.152 mol) is added dropwise to a suspension of 2-amino-5-methoxybenzenesulphonic acid (0.152 mol) in thionyl chloride (0.763 mol). The reaction mixture is heated very gradually to 70° C. and is maintained at that temperature for 1.5 hours. After cooling, the stirred reaction solution is treated by the addition of 20 ml of toluene. A precipitate is formed which is rapidly filtered off, rinsed with toluene and then dried at 40° C. in vacuo in the presence of KOH pellets, to yield the title product.

1. temperatureis maintained at that temperature for 1.5 hours
2. temperatureAfter cooling
3. customthe stirred reaction solution
4. customA precipitate is formed which
5. filtrationis rapidly filtered off
6. washrinsed with toluene
7. dry with materialdried at 40° C. in vacuo in the presence of KOH pellets