Acetic Acid → HCID 11222675, compound

HRID 882742Notes

Reaction equation

HRID 882742 reaction equation
[C:1](O)(=[O:3])[CH3:2].Cl.[NH2:6][C:7]1[CH:30]=[CH:29][CH:28]=[CH:27][C:8]=1[C:9]([NH:11][C:12]1[CH:17]=[CH:16][C:15]([N:18]2[CH:24]3[CH2:25][CH2:26][N:21]([CH2:22][CH2:23]3)[CH2:20][CH2:19]2)=[CH:14][CH:13]=1)=[O:10].C([O-])(=O)C.[Na+].C(=O)(O)[O-].[Na+]>O>[C:1]([NH:6][C:7]1[CH:30]=[CH:29][CH:28]=[CH:27][C:8]=1[C:9]([NH:11][C:12]1[CH:13]=[CH:14][C:15]([N:18]2[CH:24]3[CH2:25][CH2:26][N:21]([CH2:22][CH2:23]3)[CH2:20][CH2:19]2)=[CH:16][CH:17]=1)=[O:10])(=[O:3])[CH3:2]

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 516892Sodium BicarbonateHCID 517045Sodium AcetateHCID 68566395HCID 68566395, compound

Product 1

HCID 11222675HCID 11222675, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Acetic acid (2 ml) was added to a mixture of 2-Amino-N-[4-(1,4-diaza-bicyclo[3.2.2]non-4-yl)-phenyl]-benzamide hydrochloric acid salt (365 mg, 1.1 mmol), sodium acetate (4.4 g, 54.2 mmol) and water (100 ml) at 0° C. The mixture was made alkaline by adding saturated sodium bicarbonate (20 ml). The mixture was extracted with ethyl acetate (3×50 ml). The product was isolated. Yield 95 mg (23%). Mp. 191° C.

Workup

  1. extractionThe mixture was extracted with ethyl acetate (3×50 ml)
  2. customThe product was isolated

Sources & evidence

ORD record
ord-617653be9e0e4041b89eb88ef9469cfd
Source dataset
uspto-grants-2012_08
Patent number
US08236793B2

Reaction notes

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