Hydrochloric Acid → [(1R,3S,4S)-1-(2-Aza-bicyclo[2.2.1]hept-3-yl)methyl]-(5-bromo-pyrimidin-2-yl)-amine

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Reaction Steps

A solution of HCl in dioxane (4.0 M, 30 mL) is added to a solution of (1R,3S,4S)-3-[(5-bromo-pyrimidin-2-ylamino)-methyl]-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester (6.63 mmol) in dioxane (30 mL). After 4 h the solvents are removed in vacuo to give a crude product which is used without further purification. LC-MS: tR=0.64 min; [M+H]+=283.0.

Provenance & Evidence