huagongshe.com
HRID882801

反应详情

EQUATION

反应方程式

HRID 882801 的结构方程式

REACTANTS

反应物

2
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CC(C)(C)OC(=O)N1[C@@H]2CC[C@@H](C2)[C@H]1CNc1ncc(Br)cn1
HCID66867454

未命名化合物

PRODUCTS

生成物

1
结构：Brc1cnc(NC[C@H]2N[C@@H]3CC[C@H]2C3)nc1
HCID66867981

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

2 次

PROCEDURE

实验过程

A solution of HCl in dioxane (4.0 M, 30 mL) is added to a solution of (1R,3S,4S)-3-[(5-bromo-pyrimidin-2-ylamino)-methyl]-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester (6.63 mmol) in dioxane (30 mL). After 4 h the solvents are removed in vacuo to give a crude product which is used without further purification. LC-MS: tR=0.64 min; [M+H]+=283.0.

WORKUP

后处理

  1. customAfter 4 h the solvents are removed in vacuo