Nitrate(1-), oxo- → HCID 66644693, compound

HRID 882850Notes

Reaction equation

HRID 882850 reaction equation
[O:1]=[C:2]1[N:6]([CH2:7][C:8]2[C:13]([F:14])=[CH:12][CH:11]=[CH:10][C:9]=2[F:15])[C@@H:5]([C:16]([OH:18])=O)[CH2:4][CH2:3]1.[NH2:19][CH:20]([CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH:21]([OH:25])[C:22]([NH2:24])=[O:23].O[NH-].O=[N-]>>[NH2:24][C:22](=[O:23])[C:21](=[O:25])[CH:20]([NH:19][C:16]([C@H:5]1[CH2:4][CH2:3][C:2](=[O:1])[N:6]1[CH2:7][C:8]1[C:9]([F:15])=[CH:10][CH:11]=[CH:12][C:13]=1[F:14])=[O:18])[CH2:26][C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

Participants

5

Reactant 4

HCID 3001380Nitrate(1-), oxo-HCID 138823553-Amino-2-hydroxy-4-phenylbutanamideHCID 66644887HCID 66644887, compoundHCID 178514248HCID 178514248, compound

Product 1

HCID 66644693HCID 66644693, compound

Procedure

Coupling of (R)-5-oxo-1-(2,6-difluorobenzyl)-pyrrolidine-2-carboxylic acid with 3-amino-2-hydroxy-4-phenylbutanamide and oxidation of the resulting hydroxyamide intermediate to the corresponding ketoamide.

Sources & evidence

ORD record
ord-714a9abe3e624e36bda24660fbc9b699
Source dataset
uspto-grants-2012_08
Patent number
US08236798B2

Reaction notes

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