HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 3-Methyl-7-(3-methyl-2-buten-1-yl)-8-bromo-xanthine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Butene, 1-bromo-3-methyl- | HCID 70092 | — |
| Reactant | 8-bromo-3-methyl-3,7-dihydro-1H-purine-2,6-dione | HCID 1548797 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Methyl-7-(3-methyl-2-buten-1-yl)-8-bromo-xanthine | HCID 3435331 | — |
Reaction Steps
50 g of 8-bromo-3-methyl-3,7-dihydropurine-2,6-dione are introduced into 900 ml of DMF, and 14.1 g of potassium carbonate are added. The suspension is heated to an internal temperature of 60° C., and 31.7 g of 1-bromo-3-methyl-2-butene are slowly added. The mixture is stirred at this temperature for 3 hours and then 1.2 l of water are added. The solid is filtered off with suction, thoroughly washed with water and dried in vacuo at 45° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08236810B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-a24f1c1c54184ce49a25acd440145cea |
| Source note | uspto-grants-2012_08 |