反应详情

[4-({2-[(3,5-Diamino-6-chloro-pyrazine-2-carbonyl)-amino]-ethyl}-methyl-amino)-butyl]-carbamic acid tert-butyl ester (0.54 g, 2.2 mmol) in DCM (10 mL) and TFA (2 mL) is stirred at RT for 1 h. The solvent is removed in vacuo and the resulting oil is dissolved in saturated aqueous sodium carbonate solution. The mixture is concentrated in vacuo and the residue is dissolved in MeOH and filtered to remove the sodium carbonate. The filtrate is concentrated in vacuo to afford the title compound. [M+H]+ 316

1. customThe solvent is removed in vacuo
2. dissolutionthe resulting oil is dissolved in saturated aqueous sodium carbonate solution
3. concentrationThe mixture is concentrated in vacuo
4. dissolutionthe residue is dissolved in MeOH
5. filtrationfiltered
6. customto remove the sodium carbonate
7. concentrationThe filtrate is concentrated in vacuo