Potassium Carbonate → HCID 14154315, compound

HRID 882989Notes

Reaction equation

HRID 882989 reaction equation
C([O:4][CH2:5][C:6]1[C:11]([Cl:12])=[C:10]([O:13][CH3:14])[CH:9]=[CH:8][N:7]=1)(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO>[Cl:12][C:11]1[C:6]([CH2:5][OH:4])=[N:7][CH:8]=[CH:9][C:10]=1[O:13][CH3:14]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 58201210HCID 58201210, compound

Product 1

HCID 14154315HCID 14154315, compoundYield 95.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

The above (3-chloro-4-methoxypyridin-2-yl)methyl acetate (570 mg) was dissolved in methanol (13 mL), and potassium carbonate (731 mg) was then added to the solution. The resulting mixture was stirred at 50° C. for 30 minutes. Thereafter, methanol was distilled away under reduced pressure, and water was then added to the residue, followed by extraction with chloroform three times. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was then distilled away under reduced pressure, so as to obtain the title compound (437 mg) as an oily substance.

Workup

  1. distillationThereafter, methanol was distilled away under reduced pressure, and water
  2. additionwas then added to the residue
  3. extractionfollowed by extraction with chloroform three times
  4. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  5. distillationthe solvent was then distilled away under reduced pressure

Sources & evidence

ORD record
ord-0835948053b0461c981ce15309a8685f
Source dataset
uspto-grants-2012_08
Patent number
US08236813B2

Reaction notes

Loading…