反应详情

温度

25 °C

3 N hydrochloric acid (0.786 ml, 2.358 mmol) was added to an ethanol (30 ml) suspension of the above 2-{4-amino-2-[(3-chloro-4-methoxy-5-methylpyridin-2-yl)methyl]-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-8-yl}-N-methylacetamide (527.52 mg, 1.183 mmol), while stirring at 25° C. The resulting mixture was stirred for 1 hour. The precipitated solid was filtered, was washed with ethanol (6 ml), and was then dried under reduced pressure at 40° C. for 30 minutes, so as to obtain the title compound (531.09 mg, 1.101 mmol).

1. stirringThe resulting mixture was stirred for 1 hour
2. filtrationThe precipitated solid was filtered
3. washwas washed with ethanol (6 ml)
4. customwas then dried under reduced pressure at 40° C. for 30 minutes