Phthalic Anhydride → HCID 178514958, compound

HRID 883043Notes

Reaction equation

HRID 883043 reaction equation
[NH2:1][C:2]1[CH:6]=[CH:5][NH:4][N:3]=1.[C:7]1(=O)[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9](=[O:16])[O:8]1>C(O)(=O)C>[NH:4]1[CH:5]=[CH:6][C:2]([N:1]2[C:7](=[O:8])[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]2=[O:16])=[N:3]1

Participants

4

Reactant 2

HCID 6811Phthalic AnhydrideHCID 178418806HCID 178418806, compound

Product 1

HCID 178514958HCID 178514958, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
130 °C

Procedure

1.2 3-Amino-pyrazole (278 mmol) is dissolved in acetic acid (240 ml) and isobenzofurane-1,3-dione (1 eq.) is added. The reaction solution is heated to 130° C. for 14 h. After cooling to RT, the precipitate is filtrated and washed with ethylacetate/heptane (1:1). 2-(1H-Pyrazol-3-yl)-isoindole-1,3-dione is obtained as a colourless powder; HPLC (Method B): 2.69 min; LC-MS (Method B): 1.360 min, 214.15 (M+H+).

Workup

  1. temperatureAfter cooling to RT
  2. filtrationthe precipitate is filtrated
  3. washwashed with ethylacetate/heptane (1:1)

Sources & evidence

ORD record
ord-cc77030aa04c431ca671908bee1d6d56
Source dataset
uspto-grants-2012_08
Patent number
US08236824B2

Reaction notes

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