4-Bromo-2-(trifluoromethoxy)iodobenzene → 7-(4-Bromo-2-trifluoromethoxy-phenyl)-1-ethyl-4,4,6-trimethyl-3,4-dihydro-1H-quinolin-2-one

HRID 883069Notes

Reaction equation

HRID 883069 reaction equation
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([CH3:22])=[C:10](B3OC(C)(C)C(C)(C)O3)[CH:11]=2)[C:6]([CH3:24])([CH3:23])[CH2:5][C:4]1=[O:25])[CH3:2].[Br:26][C:27]1[CH:32]=[CH:31][C:30](I)=[C:29]([O:34][C:35]([F:38])([F:37])[F:36])[CH:28]=1>>[Br:26][C:27]1[CH:32]=[CH:31][C:30]([C:10]2[CH:11]=[C:12]3[C:7]([C:6]([CH3:23])([CH3:24])[CH2:5][C:4](=[O:25])[N:3]3[CH2:1][CH3:2])=[CH:8][C:9]=2[CH3:22])=[C:29]([O:34][C:35]([F:36])([F:37])[F:38])[CH:28]=1

Participants

3

Reactant 2

HCID 27364224-Bromo-2-(trifluoromethoxy)iodobenzeneHCID 219664431-Ethyl-4,4,6-trimethyl-7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,4-dihydro-1H-quinolin-2-one

Product 1

HCID 686656347-(4-Bromo-2-trifluoromethoxy-phenyl)-1-ethyl-4,4,6-trimethyl-3,4-dihydro-1H-quinolin-2-one

Procedure

Compound 5B was prepared from Compound 5A and 4-bromo-1-iodo-2-trifluoromethoxy-benzene using a the conditions described for Example 1B. MS (electrospray): mass calculated for C21H21BrF3NO2, 455.07; m/z found 456.1 [M+H]+.

Sources & evidence

ORD record
ord-deb208499f1f44c4b54ab226522095bc
Source dataset
uspto-grants-2012_08
Patent number
US08236819B2

Reaction notes

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