反应详情

To 4′-Nitro-biphenyl-4-sulfonyl chloride (1.0 g, 3.2 mmol), dissolved in pyridine (5.0 ml) was added 2-aminothiazole (1.6 g, 16.0 mmol) and the mixture was stirred at rt for 72 h. Pouring the reaction mixture into ice-water gave a precipitate that was filtered and dried to obtain 4′-Nitro-biphenyl-4-sulfonic acid thiazol-2-ylamide (0.6 g, 53%). LC/MS (10-99% CH3CN), M/Z: M+1 obs=362.2; tR=2.95 min.

1. customgave a precipitate that
2. filtrationwas filtered
3. customdried